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Pyoderma gangrenosum

Pyoderma gangrenosum is a rare skin condition that causes large, painful ulcers. Treatment from a GP or skin specialist can help.

Check if you have pyoderma gangrenosum

The main symptom of pyoderma gangrenosum is a large, painful ulcer on your skin.

It usually starts as a small bump, spot or blood blister that gets bigger quickly and turns into an ulcer.

Sometimes you may have more than 1 ulcer.

Pyoderma gangrenosum ulcers:

  • usually appear on the legs or chest
  • may also appear around a cut or graze, a stoma (where part of your bowel is brought through an opening made in your tummy), or cuts from surgery
  • may leak fluid
Pyoderma gangrenosum ulcer on white skin. The ulcer is dark pink underneath. It is light purple around the edge.
On white skin, the pyoderma gangrenosum ulcer will often be blue or purple around the edge.
A pyoderma gangrenosum ulcer on the leg shown on dark brown skin. The ulcer looks red and around it is darker and slightly purple.
On brown or black skin, the skin around the pyoderma gangrenosum ulcer may be darker than the rest of the skin.

Other symptoms include:

  • stiff joints
  • aching and painful muscles
  • a high temperature
Information:

If you're not sure it's pyoderma gangrenosum

Other conditions can have similar symptoms to pyoderma gangrenosum, such as venous leg ulcers, injuries to the skin, insect bites, skin tumours or infection.

Do not try to diagnose the problem yourself. See a GP if you're worried.

Non-urgent advice: See a GP if:

  • you have a skin ulcer that's not getting better

Treatment for pyoderma gangrenosum

How pyoderma gangrenosum is treated depends on how severe it is.

It can take a long time for the ulcers to heal and you may have scars.

Treatment may include:

  • creams or ointments
  • bandages and dressings to protect the ulcer
  • medicines to calm or control your body's immune system
  • steroid injections
  • antibiotics

Rarely, you may need surgery remove the ulcers.

Causes of pyoderma gangrenosum

It's not always clear what causes pyoderma gangrenosum. It may be an autoimmune disease, where the body's natural defence system (immune system) attacks healthy parts of your body.

It can also sometimes happen after an injury to the skin.

You may be more likely to get pyoderma gangrenosum if you have certain conditions, including:

You may also be more likely to get pyoderma gangrenosum if you take certain medicines.

Page last reviewed: 21 March 2024
Next review due: 21 March 2027

Images provided by DermNet.