Taking duloxetine with other medicines and herbal supplements

Cautions with other medicines

Some medicines and duloxetine can affect each other and increase the chances of you having side effects.

Tell your doctor or pharmacist if you're taking:

• any other medicines for depression – some rarely used antidepressants can affect duloxetine and cause very high blood pressure even after you have stopped taking them
• medicine used to help prevent blood clots, such as warfarin
• diazepam, chlorphenamine or other medicines that can make you feel more sleepy
• tramadol – this can increase the chances of you having certain side effects

Mixing duloxetine with herbal remedies and supplements

Do not take the herbal remedy St John's wort while you're being treated with duloxetine, as this will increase your risk of side effects.

There's not enough information to say that other herbal remedies and supplements are always safe to take with duloxetine. They're not tested in the same way as pharmacy and prescription medicines.