Common questions about edoxaban

Edoxaban is a type of medicine known as an anticoagulant. It makes your blood clot more slowly.

Blood clotting (thickening) is a complicated process involving substances called clotting factors.

Clotting factors are made by the liver and help stop bleeding. They work with blood cells called platelets that trigger the clotting process to make sure your blood clots properly.

Edoxaban works by stopping a clotting factor called factor Xa from working. This thins your blood so it takes longer to clot.

Edoxaban works within a few hours of taking it.

Edoxaban is safe to take for a long time. There do not seem to be any lasting harmful effects from taking it for many months and years.

Do not stop taking edoxaban without talking to your doctor.

If you stop taking edoxaban, your blood will start clotting at the same rate as before you started taking it, usually within a day or two of stopping.

This means that you may be at increased risk of serious problems like strokes, heart attacks, deep vein thrombosis (DVT) or pulmonary embolism.

There are several other anticoagulants available as tablets or capsules. They include rivaroxaban, apixaban, dabigatran and warfarin.

There are also anticoagulants that you take by injecting them. These include heparin, enoxaparin, dalteparin and tinzaparin.

Not all medicines that prevent blood clots are suitable for everyone. Talk to your doctor or pharmacist to find out why you've been recommended a particular medicine.

You will need to carry an anticoagulant alert card with you at all times.

If you have an accident, it's important that the person treating you knows you are taking an anticoagulant.

Because of the risk of bleeding, your dose of edoxaban may need to be lowered or stopped a few days before you have an operation.

Tell the surgeon that you're taking edoxaban and show them your anticoagulant alert card.

Also tell anyone else involved with your care, such as your anticoagulant specialist, so they can arrange any changes to your medicine for you.

You can still go to your dentist as usual. But tell your dentist that you're taking edoxaban, and show them your anticoagulant alert card, before you have any treatment. This is especially important if you need to have a tooth out.

Most people do not need to change their edoxaban dose but your dentist may contact your doctor for advice before starting the dental treatment.

You can have vaccinations while taking edoxaban.

Before you have them, be sure to show your anticoagulant alert card to the nurse or doctor. It's important to tell them that you are taking edoxaban in case there is any bleeding at the injection site.

It might help prevent bruising if you press on the injection site for 10 minutes after the vaccination.

You can continue to take part in non-contact sports such as running, athletics, cycling, tennis and badminton. But be sure to use the right protective clothing or equipment, like wearing a helmet when riding your bike.

Avoid all contact sports, particularly martial arts and kickboxing. This is because these types of sports could lead to an injury, which would further increase the risk of bleeding.

Having a body piercing or tattoo is not recommended while you're taking edoxaban. This is because of the increased risk of bleeding and infection.

If you still want to go ahead, talk to your doctor about your specific risks in case you need antibiotics.

And let the tattooist or piercer know beforehand that you're taking an anticoagulant medicine.

Edoxaban does not stop any type of contraception from working, including the combined contraceptive pill, progestogen-only pill and emergency contraception.

However, if edoxaban makes you sick (vomit), your contraceptive pills may not protect you from pregnancy. Look on the pill packet to find out what to do.

Find out more:

• What to do if you're sick or have diarrhoea when taking the combined pill
• What to do if you're sick or have diarrhoea when taking the progestogen-only pill

Most people can drive or ride a bike while taking edoxaban.

But if taking edoxaban makes you feel dizzy or lightheaded, then do not drive, cycle or use tools or machinery until this feeling goes away.

You can drink alcohol in moderation while taking edoxaban.

Drinking heavily, especially binge drinking lots of alcohol in one go, is dangerous while taking edoxaban. The alcohol can increase the risk of bleeding.

Apart from being careful with alcohol there are no foods or drinks you need to avoid while taking edoxaban.

It's thought that cannabis can increase your risk of serious bleeding.

It's not clear how other recreational drugs like cocaine and heroin affect edoxaban. They could be potentially dangerous.

Injecting while taking edoxaban will increase your risk of bleeding.

Talk to your doctor if you think you might use recreational drugs while taking edoxaban.

Find out more about the side effects of some recreational drugs on the Frank website.

You can reduce your risk of having a blood clot by making changes to your lifestyle, such as:

• giving up smoking
• eating a healthy, balanced diet
• getting regular exercise
• keeping to a healthy weight or losing weight if you need to