Taking spironolactone with other medicines and herbal supplements - Brand name: Aldactone

Cautions with other medicines

Some medicines affect spironolactone and stop it working properly or increase the chances of you having side effects.

Tell your doctor if you're taking any of these medicines:

• eplerenone, a medicine used to treat high blood pressure which works in a similar way to spironolactone
• other diuretics – do not take diuretics that increase potassium levels (such as amiloride) with spironolactone. You can take other diuretics (such as furosemide) with spironolactone if your doctor recommends it
• other medicines that increase your potassium levels. Examples include some medicines that help to prevent blood clots, such as enoxaparin, and some antibiotics, such as trimethoprim
• ACE inhibitors, used to treat high blood pressure and heart failure, such as ramipril, lisinopril, perindopril or enalapril
• digoxin, a medicine used to treat an irregular heartbeat
• painkillers known as non-steroidal anti-inflammatory drugs (NSAIDs), including diclofenac, ibuprofen, naproxen or aspirin

Mixing spironolactone with medicines that you buy from a pharmacy or shop

Do not take NSAIDs such as ibuprofen with spironolactone unless your doctor says it's OK.

Some products to help symptoms of indigestion and urinary tract infections (UTIs) contain potassium, and may not be suitable while you're taking spironolactone. Speak to a pharmacist or doctor to see if these medicines are safe to take with spironolactone.

Mixing spironolactone with herbal remedies and supplements

Do not take supplements that are high in potassium, such as Sando K tablets or Kay-Cee-L syrup. Taking these with spironolactone can cause your potassium levels to become too high.

There's very little information about taking other herbal remedies and supplements with spironolactone. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.