Skip to main content

About sulfasalazine

Sulfasalazine is used to treat ulcerative colitis, Crohn's disease and other types of inflammatory bowel disease.

It can also be used to treat rheumatoid arthritis.

It belongs to a group of medicines called aminosalicylates. These medicines help to reduce redness and swelling (inflammation) and can help with healing.

Sulfasalazine is available on prescription only.

It comes as tablets or a liquid that your swallow. It also comes as suppositories (a medicine that you push into your bottom).

Some people take sulfasalazine together with steroids to improve their symptoms.

Key facts

  • Different types of sulfasalazine work on different parts of your gut. Suppositories are prescribed for the end part of the bowel.
  • You'll usually need blood tests, liver tests and kidney tests before you start treatment with sulfasalazine, and then regular monitoring tests.
  • Drink plenty of fluids when taking sulfasalazine to help prevent possible kidney problems.
  • Common side effects of sulfasalazine include indigestion and feeling sick. It can also turn your pee orange and stain certain types of soft contact lenses.
  • If sulfasalazine makes you feel dizzy, do not drive, cycle or use machinery or tools until you feel better.

Page last reviewed: 5 March 2025
Next review due: 5 March 2028