Taking sulfasalazine with other medicines and herbal supplements

Cautions with other medicines

There are some medicines that can affect how sulfasalazine works.

Tell your doctor or pharmacist before starting to take or use sulfasalazine if you're taking any other medicines, including:

• digoxin, a medicine for heart problems
• medicines for high blood sugar or diabetes, such as metformin or glibenclamide
• methenamine, a type of antibiotic sometimes used for treating urinary tract infections (UTIs)
• folic acid, often taken in first 12 weeks of pregnancy, as it may be less well absorbed so you may need to take a higher dose than usual
• azathioprine or mercaptopurine, taken for rheumatoid arthritis or to prevent organ rejection after a transplant
• methotrexate, which is usually used to treat rheumatoid arthritis

Mixing sulfasalazine with herbal remedies and supplements

There's not enough information to say that complementary medicines and herbal remedies are safe to take with sulfasalazine. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.