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Taking tolterodine with other medicines and herbal supplements - Brand names: Neditol, Detrusitol, Mariosea

Cautions with other medicines

Some medicines and tolterodine can affect each other. This can increase the chance of side effects.

Tell your doctor if you're taking any other medicines, including:

  • antibiotics like erythromycin or clarithromycin
  • itraconazole or fluconazole, which are used to treat fungal infections
  • medicines used to treat HIV
  • anti-sickness medicines like metoclopramide, prochlorperazine or domperidone
  • amiodarone, sotalol, quinidine or procainamide, which are used to treat irregular heartbeats
  • other medicines that work in a similar way to tolterodine, such as fesoterodine
  • any medicines used to treat irritable bowel syndrome, asthma, incontinence, motion sickness or movement disorders related to Parkinson's disease, that work in a similar way to tolterodine
  • phenothiazines, clozapine, haloperidol or benperidol, medicines for mental health problems
  • donepezil, rivastigmine, galantamine or tacrine, medicines used for dementia
  • medicines for depression such as amitriptyline, imipramine or dosulepin (tricyclic antidepressants)
  • medicines used to make you feel sleepy (sedatives)

These are not all the medicines that may cause problems if you take them with tolterodine. For a full list, see the leaflet inside your medicine packet.

Taking tolterodine with painkillers

It's safe to take tolterodine with everyday painkillers like paracetamol.

Mixing tolterodine with herbal remedies and supplements

Some herbal remedies can make you feel sleepy, cause a dry mouth, or make it difficult to pee. Their effect is similar to tolterodine. This can increase your risk of getting side effects or make your side effects worse.

There's not enough information to say that other complementary medicines and herbal remedies are safe to take with tolterodine. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.

Important: Medicine safety

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

Page last reviewed: 25 March 2025
Next review due: 25 March 2028