Taking topiramate with other medicines and herbal supplements

Cautions with other medicines

There are some medicines that may affect how topiramate works or topiramate may affect how they work.

Tell your doctor if you're taking any of these medicines:

• medicines used to treat diabetes, such as metformin, glibenclamide or pioglitazone
• medicines used to treat depression or anxiety, such as venlafaxine or amitriptyline
• medicines for heart problems or high blood pressure, such as diltiazem, hydrochlorothiazide or propranolol
• antipsychotic medicines, such as risperidone
• any other epilepsy medicines

Mixing topiramate with herbal remedies and supplements

Tell your doctor or pharmacist if you need to take high doses of vitamin C or calcium supplements. Taking these supplements can increase a risk of kidney stones.

Do not take St John's wort, the herbal remedy for depression, while you're being treated with topiramate. It may make topiramate less effective.

There's not enough information to say that other herbal remedies and supplements are safe to take with topiramate. They're not tested in the same way as pharmacy and prescription medicines.